Cannot Intubate, Cannot Ventilate
Oxygenation is paramount. Default to whatever works. Surgical airway last but don't delay.
Recognize
- Failed mask ventilation AND failed laryngoscopy
- Falling SpO₂ despite attempts
- Bradycardia heralding hypoxic arrest
Doses
Sequenced Actions
- 1Call for help — early
- Second anesthesiologist
- Surgeon at the head of the bed
- ENT / general surgery for surgical airway
- Get the difficult airway cart
- 2Optimize mask ventilation
- 100% O₂, two-handed mask + jaw thrust
- Oral + nasal airway
- Reposition: sniffing position, head extension, ramp obese patients
- ↑ PIP up to 25–30 cmH₂O if needed
- 3Place a supraglottic airway (LMA)
- Single best rescue maneuver
- Use 2nd-gen LMA (Supreme, ProSeal, i-gel)
- Adequate ventilation through LMA buys time
- 4If LMA works
- Maintain SGA, oxygenate, then decide:
- Wake patient up if elective
- Intubate via SGA with fiberoptic if surgery must proceed
- Proceed with surgery via SGA if low-risk
- Convert to surgical airway electively if needed
- 5If LMA fails — CICV
- Call out "CANNOT INTUBATE, CANNOT VENTILATE" loudly
- Proceed to emergency front-of-neck airway — DO NOT WAIT
- Concurrently: maximize O₂ via nasal cannula (apneic oxygenation)
- If sugammadex available and ROC given: 16 mg/kg sugammadex to attempt to wake the patient
- 6Scalpel-bougie-tube cricothyrotomy
1. Extend the neck; identify the cricothyroid membrane 2. Vertical skin incision over cricothyroid membrane (~8 cm long) 3. Horizontal stab through the membrane 4. Insert bougie caudally 5. Railroad 6.0 ETT over bougie 6. Inflate cuff, confirm with EtCO₂, secure > Avoid needle cricothyrotomy if surgical option available — jet ventilation has high complication rate (barotrauma).
- 7Post-event
- Document airway exam, attempts, devices used, complications
- Award patient a difficult airway letter for medical record
- MedicAlert bracelet
- Notify patient and family
Common Pitfalls
- Delaying SGA placement after one or two failed intubation attempts.
- Insisting on more laryngoscopy attempts in a desaturating patient.
- Choosing needle cricothyrotomy over surgical when adult equipment is available.
- Forgetting sugammadex when roc was used.
References & Further Reading
- 1GuidelineOpen source
Apfelbaum JL, Hagberg CA, Connis RT, et al. 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway. Anesthesiology. 2022;136(1):31-81.
- 2Journal
Cook TM, Woodall N, Frerk C; Fourth National Audit Project. Major complications of airway management in the UK (NAP4). Br J Anaesth. 2011;106(5):617-642.
- 3WebOpen source
Stanford Anesthesia Cognitive Aid Group. Stanford Anesthesia Emergency Manual. emergencymanual.stanford.edu.
- 4Textbook
Gropper MA, Miller RD, Cohen NH, et al., eds. Miller's Anesthesia. 9th ed. Philadelphia: Elsevier; 2020.
Citations are provided to direct further study. Always check the most current edition of guidelines and society recommendations — the information in this chapter is a teaching summary, not primary source material.